Rapid Influenza Diagnostic Tests

influenza a ab eia

influenza a ab eia

Background

Rapid influenza diagnostic tests (RIDTs) are immunoassays that can identify the presence of influenza A and B viral nucleoprotein antigens in respiratory specimens, and display the result in a qualitative way (positive vs. negative) (1). In the United States, a number of RIDTs are commercially available. (See “Table 1: Influenza Virus Testing Methods” and “Table 2: Characteristics of Rapid Influenza Diagnostic Tests”.) The reference standards for laboratory confirmation of influenza virus infection in respiratory specimens are reverse transcription-polymerase chain reaction (RT-PCR) or viral culture. RIDTs can yield results in a clinically relevant time frame, i.e., less than approximately 15 minutes. However, RIDTs have limited sensitivity to detect influenza viruses in respiratory specimens compared to RT-PCR or viral culture and negative RIDT test results should be interpreted with caution given the potential for false negative results, especially during peak influenza activity in a community. Some RIDTs use analyzer reader devices to standardize result interpretation.

1 RIDTs do not include rapid molecular assays that have higher sensitivity to detect influenza viruses in respiratory specimens compared to RIDTs. See Guidance for Clinicians on the Use of RT-PCR and Other Molecular Assays for Diagnosis of Influenza Virus Infection for more information.

 

influenza a ab eia
influenza a ab eia

Advantages and Disadvantages of RIDTs

Advantages
  • Produce quick result in less than approximately 15 minutes, simple to perform
  • Some RIDTs are cleared for office/bedside use. RIDTs that have been CLIA waived can be used in settings that include point-of-care.
Disadvantages
  • Sub-optimal test sensitivity, false negative results are common, especially when influenza activity is high
  • Sensitivity of RIDTs to detect influenza B viral antigens is lower than for detection of influenza A viral antigens.
  • Although specificity is high, false positive results can also occur, especially during times when influenza activity is low.
  • Some RIDTs distinguish between influenza A or B viruses while others do not. RIDTs that provide results on the type of influenza virus (e.g., influenza A or B virus), do not provide information on influenza A virus subtype [e.g., A(H1N1)pdm09 versus A(H3N2)] or specific virus strain information (e.g., degree of similarity to vaccine strains). RIDTs cannot distinguish between seasonal influenza A virus infection and novel influenza A virus infection (due to infection with avian or variant influenza A viruses).

 

Use of RIDTs in Clinical Decision-making

RIDTs may be used to help with diagnostic and treatment decisions for patients in clinical settings, such as whether to prescribe antiviral medications. However, due to the limited sensitivities, negative results of RIDTs do not exclude influenza virus infection in patients with signs and symptoms suggestive of influenza. Therefore, if clinically indicated, antiviral treatment should not be withheld from patients with suspected influenza, even if they test negative by RIDT, and further influenza testing of respiratory specimens by molecular assays may be indicated. More information about Antiviral Drugs and recommendations on their use.

Testing is not needed for all patients with signs and symptoms of influenza to make antiviral treatment decisions (See Figures 1-4). Once influenza activity has been documented in the community or geographic area, a clinical diagnosis of influenza can be made for outpatients with signs and symptoms consistent with suspected influenza, especially during periods of peak influenza activity in the community.

 

Influenza A protein

30-1306 1 ml
EUR 295
Description: Purified native Influenza A protein

Influenza A protein

30-AI50 1 ml
EUR 262
Description: Purified Influenza A protein (H1N1 strain)

Influenza A protein

30-AI60 1 ml
EUR 262
Description: Purified Influenza A protein (H3N2 strain)

Influenza A antibody

10R-I131a 1 mg
EUR 476
Description: Mouse monoclonal Influenza A antibody

Influenza A antibody

10R-I131b 1 mg
EUR 489
Description: Mouse monoclonal Influenza A antibody

Influenza A antibody

10C-CR1306M1 100 ug
EUR 506
Description: Mouse monoclonal Influenza A antibody

Influenza A antibody

10C-CR1306M2 100 ug
EUR 281
Description: Mouse monoclonal Influenza A antibody

Influenza A antibody

10-1103 500 ug
EUR 349
Description: Mouse monoclonal Influenza A antibody

Influenza A antibody

10-1241 500 ug
EUR 349
Description: Mouse monoclonal Influenza A antibody

Influenza A antibody

10-1243 500 ug
EUR 349
Description: Mouse monoclonal Influenza A antibody

Influenza A antibody

10-7866 1 mg
EUR 403
Description: Mouse monoclonal Influenza A antibody

Influenza A antibody

10-7867 1 mg
EUR 403
Description: Mouse monoclonal Influenza A antibody

Influenza A antibody

10-I50A 1 mg
EUR 503
Description: Mouse monoclonal Influenza A antibody

Influenza A antibody

10-I50B 1 mg
EUR 392
Description: Mouse monoclonal Influenza A antibody

Influenza A antibody

10-I50C 1 mg
EUR 392
Description: Mouse monoclonal Influenza A antibody

Influenza A antibody

10-I50D 1 mg
EUR 279
Description: Mouse monoclonal Influenza A antibody

Influenza A antibody

10-I50E 1 mg
EUR 279
Description: Mouse monoclonal Influenza A antibody

Influenza A antibody

10-I50F 1 mg
EUR 273
Description: Mouse monoclonal Influenza A antibody

Influenza A antibody

10-I50G 1 mg
EUR 408
Description: Mouse monoclonal Influenza A antibody

Influenza A antibody

10-I50H 1 mg
EUR 541
Description: Mouse monoclonal Influenza A antibody

Influenza A antibody

10-I50I 1 mg
EUR 408
Description: Mouse monoclonal Influenza A antibody

Influenza A antibody

10-I50K 1 mg
EUR 273
Description: Mouse monoclonal Influenza A antibody

Influenza A antibody

10-I50L 1 mg
EUR 300
Description: Mouse monoclonal Influenza A antibody

Influenza A antibody

10-I50M 1 mg
EUR 300
Description: Mouse monoclonal Influenza A antibody

Influenza A antibody

10-I50N 1 mg
EUR 300
Description: Mouse monoclonal Influenza A antibody

Influenza A antibody

10-I50O 1 mg
EUR 300
Description: Mouse monoclonal Influenza A antibody

Influenza A antibody

10-I50P 1 mg
EUR 300
Description: Mouse monoclonal Influenza A antibody

Influenza A antibody

10-I50Q 1 mg
EUR 273
Description: Mouse monoclonal Influenza A antibody

Influenza A antibody

10-I50R 1 mg
EUR 273
Description: Mouse monoclonal Influenza A antibody

Influenza A antibody

10-I50S 1 mg
EUR 273
Description: Mouse monoclonal Influenza A antibody

Influenza A antibody

10-I50T 1 mg
EUR 273
Description: Mouse monoclonal Influenza A antibody

Influenza A antibody

10-I50U 1 mg
EUR 273
Description: Mouse monoclonal Influenza A antibody

Influenza A antibody

10-1096 500 ug
EUR 208
Description: Mouse monoclonal Influenza A antibody

Influenza A antibody

10-1097 1 mg
EUR 349
Description: Mouse monoclonal Influenza A antibody

Influenza A antibody

10-1098 1 mg
EUR 605
Description: Mouse monoclonal Influenza A antibody

Influenza A antibody

10-1099 1 mg
EUR 605
Description: Mouse monoclonal Influenza A antibody

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